University of Pennsylvania

Publications

See Google Scholar for a complete chronological list of papers and patents.

Highlighted

ADAR1 editing is necessary for only a small subset of cytosolic dsRNAs to evade MDA5-mediated autoimmunity
ADAR1 editing is necessary for only a small subset of cytosolic dsRNAs to evade MDA5-mediated autoimmunity
Tao Sun*, Qin Li*, Jonathan M. Geisinger, Shi-Bin Hu, Boming Fan, Shichen Su, Waitang Tsui, Hongchao Guo, Jinbiao Ma, Jin Billy Li
Nature Genetics   ·   23 Dec 2025   ·   doi:10.1038/s41588-025-02430-9
RNA editing underlies genetic risk of common inflammatory diseases
RNA editing underlies genetic risk of common inflammatory diseases
Qin Li, Michael J. Gloudemans, Jonathan M. Geisinger, Boming Fan, François Aguet, ..., Yang I. Li, Jin-Biao Ma, Jonathan K. Pritchard, Stephen B. Montgomery, Jin Billy Li
Nature   ·   03 Aug 2022   ·   doi:10.1038/s41586-022-05052-x
RNA editing Autoimmune disease Genetic variantion ADAR1 MDA5
Dynamic landscape and regulation of RNA editing in mammals
Dynamic landscape and regulation of RNA editing in mammals
Meng How Tan*, Qin Li*, Raghuvaran Shanmugam, Robert Piskol, Jennefer Kohler, ..., Charles E. Samuel, Mary A. O’Connell, Carl R. Walkley, Kazuko Nishikura, Jin Billy Li
Nature   ·   12 Oct 2017   ·   doi:10.1038/nature24041
RNA editing ADAR GTEx

All

2025

ADAR1 editing is necessary for only a small subset of cytosolic dsRNAs to evade MDA5-mediated autoimmunity
ADAR1 editing is necessary for only a small subset of cytosolic dsRNAs to evade MDA5-mediated autoimmunity
Tao Sun*, Qin Li*, Jonathan M. Geisinger, Shi-Bin Hu, Boming Fan, Shichen Su, Waitang Tsui, Hongchao Guo, Jinbiao Ma, Jin Billy Li
Nature Genetics   ·   23 Dec 2025   ·   doi:10.1038/s41588-025-02430-9
Smooth muscle expression of RNA editing enzyme ADAR1 controls activation of the RNA sensor MDA5 in atherosclerosis
Smooth muscle expression of RNA editing enzyme ADAR1 controls activation of the RNA sensor MDA5 in atherosclerosis
Chad S Weldy, Qin Li, João P Monteiro, Tim S Peters, Hongchao Guo, ..., Michal Mokry, Clint L Miller, Sander W van der Laan, Jin Billy Li, Thomas Quertermous
Nature Cardiovascular Research   ·   16 Sep 2025   ·   doi:10.1038/s44161-025-00710-5

2024

GGNBP2 regulates MDA5 sensing triggered by self double-stranded RNA following loss of ADAR1 editing
GGNBP2 regulates MDA5 sensing triggered by self double-stranded RNA following loss of ADAR1 editing
Jacki E Heraud-Farlow, Scott R Taylor, Alistair M Chalk, Adriana Escudero, Shi-Bin Hu, ..., Jin Billy Li, Miguel Fidalgo, Diana Guallar, Kaylene J Simpson, Carl R Walkley
Science Immunology   ·   22 Nov 2024   ·   doi:10.1126/sciimmunol.adk0412

2023

Ablation of Adar1 in myeloid cells imprints a global antiviral state in the lung and heightens early immunity against SARS-CoV-2
Ablation of Adar1 in myeloid cells imprints a global antiviral state in the lung and heightens early immunity against SARS-CoV-2
Julia Z. Adamska, Rohit Verma, Shakti Gupta, Thomas Hagan, Florian Wimmers, ..., Shankar Subramaniam, Carl R. Walkley, Mehul S. Suthar, Jin Billy Li, Bali Pulendran
Cell Reports   ·   01 Jan 2023   ·   doi:10.1016/j.celrep.2023.112038

2022

RNA editing underlies genetic risk of common inflammatory diseases
RNA editing underlies genetic risk of common inflammatory diseases
Qin Li, Michael J. Gloudemans, Jonathan M. Geisinger, Boming Fan, François Aguet, ..., Yang I. Li, Jin-Biao Ma, Jonathan K. Pritchard, Stephen B. Montgomery, Jin Billy Li
Nature   ·   03 Aug 2022   ·   doi:10.1038/s41586-022-05052-x
RNA editing Autoimmune disease Genetic variantion ADAR1 MDA5

2021

Learning cis-regulatory principles of ADAR-based RNA editing from CRISPR-mediated mutagenesis
Learning cis-regulatory principles of ADAR-based RNA editing from CRISPR-mediated mutagenesis
Xin Liu, Tao Sun, Anna Shcherbina, Qin Li, Inga Jarmoskaite, Kalli Kappel, Gokul Ramaswami, Rhiju Das, Anshul Kundaje, Jin Billy Li
Nature Communications   ·   12 Apr 2021   ·   doi:10.1038/s41467-021-22489-2

2020

Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing
Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing
Emily C. Freund, Anne L. Sapiro, Qin Li, Sandra Linder, James J. Moresco, John R. Yates, Jin Billy Li
Cell Reports   ·   01 May 2020   ·   doi:10.1016/j.celrep.2020.107656

2017

Dynamic landscape and regulation of RNA editing in mammals
Dynamic landscape and regulation of RNA editing in mammals
Meng How Tan*, Qin Li*, Raghuvaran Shanmugam, Robert Piskol, Jennefer Kohler, ..., Charles E. Samuel, Mary A. O’Connell, Carl R. Walkley, Kazuko Nishikura, Jin Billy Li
Nature   ·   12 Oct 2017   ·   doi:10.1038/nature24041
RNA editing ADAR GTEx